Semax

What is Semax?

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-7) fragment, modified to resist enzymatic degradation while retaining and enhancing its central nervous system effects. Developed in Russia in the 1980s by the Institute of Molecular Genetics, Semax has been extensively studied in the context of nootropic pharmacology, neuroprotection, and cognitive enhancement in preclinical and clinical research settings.

Research Context

Research has demonstrated that Semax significantly increases brain-derived neurotrophic factor (BDNF) expression — a critical growth factor for neuronal survival and synaptic plasticity — without the receptor desensitization seen with direct BDNF administration. Studies in rodent models have documented improved learning and memory performance, neuroprotection following ischemic insult, and recovery of neurological function after spinal cord injury.

Research Applications

• BDNF expression and neurotrophic factor research
• Cognitive function and memory models
• Neuroprotection following ischemia and hypoxia
• Spinal cord and neural injury recovery research
• Attention, anxiety, and dopaminergic system studies

For research use only. Not for human or animal consumption.

This compound's precise mechanism continues to be characterized through ongoing preclinical research. Investigators have proposed interactions with growth factor signaling pathways, receptor modulation, and cellular repair cascades. Consult current peer-reviewed literature for the most up-to-date mechanistic hypotheses.

Store lyophilized powder at −20°C for up to 24 months. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. Protect from light, moisture, and repeated freeze-thaw cycles. Handle in a clean laboratory environment with appropriate PPE. For research use only — not for human or animal administration.

Use our Peptide Reconstitution Calculator to determine the exact volume of bacteriostatic water to add. Allow the solvent to run down the inside of the vial slowly — do not inject directly onto the lyophilized cake. Swirl gently; do not shake. The solution should appear clear to slightly opalescent.

Orders ship in discreet, unmarked packaging with no reference to Aeternum Labs on the exterior. All shipments include full tracking and are insured against loss or damage. Most orders are dispatched within 1–2 business days. Cold-chain packaging is included where required to maintain compound integrity during transit.