Melanotan 1 (MT-1)

What is Melanotan I?

Melanotan I (afamelanotide) is a synthetic linear analogue of endogenous alpha-melanocyte-stimulating hormone. Comprising 13 amino acids, it binds to the full spectrum of melanocortin receptors (MC1R through MC5R) with particular affinity for MC1R, the primary receptor governing melanin production in melanocytes. Its linear structure distinguishes it from the cyclized Melanotan II.

Research Context

Research into Melanotan I has focused on its capacity to stimulate eumelanin production in skin cells through MC1R activation. Studies in animal models and limited human trials have documented increased skin pigmentation with reduced UV-induced erythema. More recent research has explored potential cardioprotective and anti-inflammatory properties mediated through MC3R and MC4R pathways. Investigators have also studied its potential in reducing light sensitivity disorders.

Research Applications

• Melanocortin receptor binding and activation studies
• Melanogenesis and pigmentation research
• Photoprotection mechanism investigation
• MC1R pathway studies in skin cell models
• Anti-inflammatory cascade research

For research use only. Not for human or animal consumption.

This compound's precise mechanism continues to be characterized through ongoing preclinical research. Investigators have proposed interactions with growth factor signaling pathways, receptor modulation, and cellular repair cascades. Consult current peer-reviewed literature for the most up-to-date mechanistic hypotheses.

Store lyophilized powder at −20°C for up to 24 months. Once reconstituted with bacteriostatic water, store at 4°C and use within 28 days. Protect from light, moisture, and repeated freeze-thaw cycles. Handle in a clean laboratory environment with appropriate PPE. For research use only — not for human or animal administration.

Use our Peptide Reconstitution Calculator to determine the exact volume of bacteriostatic water to add. Allow the solvent to run down the inside of the vial slowly — do not inject directly onto the lyophilized cake. Swirl gently; do not shake. The solution should appear clear to slightly opalescent.

Orders ship in discreet, unmarked packaging with no reference to Aeternum Labs on the exterior. All shipments include full tracking and are insured against loss or damage. Most orders are dispatched within 1–2 business days. Cold-chain packaging is included where required to maintain compound integrity during transit.